performed based on systematic reviews of experimental and observational studies, also using Bayesian methods.
Within the clinical analysis the efficacy and safety of the health technology under consideration in a given indication is determined in relation to alternative therapeutic options. It is developed based on scientific publications characterised by highest quality, identified during a systematic review of medical literature.
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For our customers we offer to perform full systematic reviews fulfilling all international requirements. The scope of this service is always tailored to the clients’ needs and may include:
For our clients we offer a comprehensive support and consultancy regarding appropriate data processing and representation. This may include extraction of relevant information from clinical trials and thorough analysis of heterogeneity followed by aggregation with appropriate method of meta-analysis.
Heterogeneous data significantly hamper the inference and diminish quality of the analysis. Therefore, we facilitate our customer investigating the reasons of heterogeneity using variety of statistical methods including subgroup meta-analyses or regression models.
On the customer’s request, the results of each analysis can be illustrated with high quality plots or graphs, such as forest-plots, bubble-plots, funnel-plots, etc.
Our experts may provide a complex evaluation of methodological credibility of provided evidence or analyses in order to ensure our customers that the evidence which support their activities is of high methodological quality and free from potential biases. Our services may include:
Often, head-to-head trials available in public domain do not allow to compare the intervention of interest with all relevant technologies. However, despite the lack of studies directly comparing intervention A with B, their effects can be statistically compared using methods of indirect comparison.
Depending on the number of technologies to compare and availability of clinical data indirect comparison may involve:
Well written manuscripts together with appropriate data visualization and accurate discussion of the results increase the chance for acceptance the publication in reputable peer-reviewed journals. HTA Consulting has established experience in leading the customers through the entire process of publication. Our services include: